RVTESTS supports both single variant and gene-level tests. With new implementation of the BOLT-LMM/MINQUE algorithm as well as a series of software engineering optimizations, our software package is capable of analyzing datasets of up to 1,000,000 individuals in linear mixed models on a computer workstation, which makes our tool one of the very few options for analyzing large biobank scale datasets, such as UK Biobank. It takes VCF/BGEN/PLINK format as genotype input file and takes PLINK format phenotype file and covariate file. single variant score test, burden test, variable threshold test, SKAT test, fast linear mixed model score test). It includes a variety of association tests (e.g. It can analyze both unrelated individual and related (family-based) individuals for both quantitative and binary outcomes. Since its inception, rvtests was developed as a comprehensive tool to support genetic association analysis and meta-analysis. Rvtests, which stands for Rare Variant tests, is a flexible software package for genetic association analysis for sequence datasets. Handle missing genotypes and phenotypes.
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